Antonio Conte s Serie A return with Inter will come at home to promoted Lecce, while Juventus title defence starts with a trip to Parma.
Serie A announced the fixtures for the new campaign on Monday, with the 2019-20 season set to begin on August 25.
It has been an intriguing close season in Italy, with many of the country s top clubs changing coaches.
Conte is now at Inter and former Napoli coach Maurizio Sarri is back in Serie A with defending champions Juve after leaving Chelsea.
AC Milan swapped Gennaro Gattuso for Marco Giampaolo and Roma are now under the tutelage of Paolo Fonseca.
Sarri s new side begin by travelling to Parma, while Milan go to Udinese and Roma host Genoa on the opening weekend.
3 Juventus have won all the 3 previous games played in a Serie A MD-1 vs Parma: 1990-91, 2011-12, 2012-13. Rule.
— OptaPaolo (@OptaPaolo)
Matchday one fixtures in full
Cagliari v Brescia
Fiorentina v Napoli
Hellas Verona v Bologna
Inter v Lecce
Parma v Juventus
Roma v Genoa
Sampdoria v Lazio
SPAL v Atalanta
Torino v Sassuolo
Udinese v AC Milan